Stimulating the defective immune system can kill cancer cells. According to the American Physicists Organization Network, researchers at the Loyola University in Chicago are working on a new technology that is passed through immune compromised mice and human T cells infected with HIV. Experiments can effectively stimulate the defective immune system and are expected to turn T cells into a more effective weapon against various infections and even cancer. Related papers were published in the latest issue of "Nature · Medical". Senior author of the paper, José Guevara Petino, associate professor at the School of Oncology at Strych School of Medicine at Loyola University in Chicago, said that in HIV-infected and cancer patients, T cells are usually suppressed. The technology mainly delivers a piece of DNA to the commanding cells of the immune system, instructing them to produce a special protein, and these proteins can stimulate T cells. The object of their research is CD8 T cells and antigen presenting cells, antigen presenting cells are CD8 T cell command cells. After being instructed by the command cell, CD8 T cells need assistance from other T cells to become strong, kill those infected cells or cancer cells, and remain vigilant when they encounter pathogens or cancer cells again. Andrew Zrolla, one of the leading authors of the paper, explained that tumors have many hidden abilities, and the most important one is to contain T cells from attacking tumors. They can put other T cells in the suppression phase, limiting their assistance to CD8 T cells. The researchers used a gene gun to deliver a small piece of DNA to the skin's command cell. This DNA is like a molecular key that can instruct the command cell to produce special proteins. When CD8 T cells interact with command cells, the key unlocks the potential of CD8 T cells, activating them to kill pathogens and cancer cells. With this technique, T cells will no longer need the help of other T cells to kill pathogens and cancer cells. Even if the tumor puts these helper T cells into a "cage", the T cells can still mobilize and kill the cancer cells. The researchers also expressed the hope that this technology will be used in more disease research in the future, including cancer, and clinical trials of cancer patients are expected to begin within 3 years.
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